منابع مشابه
Signal transduction in mesangial cells.
Phenotype, growth, and functional characteristics of glomerular mesangial "myofibroblasts" are under the control of multiple hormones, vasoactive agents, autacoids, and cytokines. Several parallel signal transduction pathways couple receptor occupancy with functional changes, including phospholipases C, A2, and D breakdown of membrane phospholipids, and adenylate/guanylate cyclase activation. C...
متن کاملSignal transduction in T cells.
Rapid progress was made during the past year in the delineation of the nature of the initial biochemical events triggered by the T-cell antigen receptor. Antigen-mediated activation of phospholipase C was demonstrated to require protein tyrosine phosphorylation and, most surprising, activation of the Ras family of signal transduction molecules was shown to closely follow stimulation of the T-ce...
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The use of immune checkpoint inhibitors for the treatment of cancer is revolutionizing oncology. Amongst these therapeutic agents, antibodies that block PD-L1/PD1 interactions between cancer cells and T cells are demonstrating high efficacies and low toxicities. Despite all the recent advances, very little is yet known on the molecular intracellular signaling pathways regulated by either PD-L1 ...
متن کاملEditorial: Signal Transduction in Stomatal Guard Cells
During adaptation of plants to water stress/drought, the tiny pores on the leaf surface, called “stomata,” play a very important role. Stomatal movements can modulate the entry/exit of not only CO2/water (Lawson and Blatt, 2014) but also microbial pathogens (Agurla et al., 2014; Arnaud and Hwang, 2015). The stomatal opening/closure is brought out by changes in the turgor of guard cells. The abi...
متن کاملAltered signal transduction in SLE T cells.
T cells from patients with systemic lupus erythematosus display numerous signalling abnormalities. The T cell receptor complex is rewired with the common FcRgamma chain replacing the CD3 zeta chain while the T cell surface membrane lipid rafts are aggregated. These two aberrations result in enhanced early signalling events and altered downstream signalling events. These are in turn responsible ...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1996
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)36305-x